Jesse Meyer

Credentials: PhD

Position title: Assistant Professor of Biochemistry

Email: jesmeyer@mcw.edu

My previous research as a postdoc taught me about the interface of metabolism, nutrition, and protein modifications. Specifically, as part of a R24 grant (PI: Eric Verdin), we studied how different types of nutrient excess in mice lead to different profiles of protein post-translational modifications (PTMs). Our work developed tools to automate the discovery and quantification of PTMs, and suggested succinylation of lysine residues in UCP1 in brown adipose tissue as a controller of thermogenesis. We also found that excess dietary glucose, but not excess fat, may be the primary carbon source for protein acetylation in mouse liver. My current research is more focused on basic metabolism and discovery of new metabolic regulation with multi- omic data (ie proteomics and metabolomics). We are developing new ways to collect multi-omic data more quickly, and we are developing new computational methods to integrate the data we collect. This work is supported by an R35 grant from the NIGMS. We have found new connections between metabolites and proteins that were not previously known. As a Research Base Member of the Wisconsin Diabetes Research Center, I look forward to supporting proteomic projects related to diabetes research.