3rd ANNUAL UW-MADISON DIABETES RESEARCH DAY
Date: Friday, September 9, 2022, 8:30 am – 4:00 pm
Location: H.F. DeLuca Forum, Discovery Building, 330 North Orchard St., Madison, WI 53715
Keynote speaker: Dr Philipp Scherer – Director, Touchstone Diabetes Center; UT Southwestern Medical Center
Awards:
Best Poster (2x)
KEYNOTE SPEAKER
Philipp Scherer, PhD
Director, Touchstone Diabetes Center,
UT Southwestern Medical Center
Talk title: “Adipose Tissue Organ Crosstalk in Health and Disease“
The main focus of the Scherer laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis, an effort aimed to unravel novel mechanisms and identify novel proteins that could serve as potential links between the adipocyte and the process of whole body energy homeostasis, thereby defining novel targets for pharmacological intervention and further define the role of adipose tissue as an endocrine tissue.
Agenda and Posters
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Agenda
- Breakfast – 8:30 – 9:00 am
- Welcome – 9:00 – 9:10 am
- Flash Talks – 9:10 – 10:15 am
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- Jacquelyn Adams, MD – Assistant Professor (CHS) Perinatologist Maternal-Fetal Medicine
“AT GOAL: Adopting Technology for Glucose Optimization And Lifestyle in Pregnancy – A new study in the Department of Obstetrics” - Vanessa Leone, PhD Assistant Professor of Animal Biologics and Metabolism Research
“Small intestinal host-microbe diurnal rhythms in metabolic dysfunction” - Rachel Jones Lipinski, PhD Fellow with Dr. Brian Smith
“Urea Nitrogen Salvage Contributes to Protein Conservation During Winter Fasting in Hibernators” - Meng-Jung Wen Graduate Student with Dr. Olayinka Shiyanbola
“Convergent loss and non-parallel reacquisition of gluconeogenesis in budding and fission yeasts”
- Jacquelyn Adams, MD – Assistant Professor (CHS) Perinatologist Maternal-Fetal Medicine
- Break/Poster Session – 10:15 – 11:00 am
- Flash Talks – 11:00 – 12:00 pm
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- Stephanie Olivier Van Stichelen, PhD – Assistant Professor of Biochemistry
“O-GlcNAcylation and sex-specific placental deregulation in gestational diabetes” - John Corbett, PhD – Professor of Biochemistry
“Cellular stress is negatively associated with cytokine signaling in human pancreatic β-cells” - Christopher Emfinger, PhD – Postdoctoral Fellow with Dr. Alan Attie
“Variation in mouse islet Ca2+ responses reveals novel regulators of human islet function” - Erli Jin Graduate Student with Dr. Matthew Merrins
“Genetic deletion of mitochondrial PEP carboxykinase (PCK2) in pancreatic α cells increases amino acid-stimulated Ca2+ influx and boosts the excitability of neighboring β-cells”
- Stephanie Olivier Van Stichelen, PhD – Assistant Professor of Biochemistry
- Lunch/Poster Session – 12:00 – 1:15 pm
- Flash Talks – 1:15 – 2:00 pm
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- Roomasa Channa, MD Assistant Professor of Ophthalmology and Visual Sciences
“Studying diabetic retinal diseases using AI and Big Data” - David Harris, MD Assistant Professor of Surgery
“Sleeve gastrectomy induces a metabolic shift toward glucose metabolism and protects animals against obesogenic insults.”
- Roomasa Channa, MD Assistant Professor of Ophthalmology and Visual Sciences
- Keynote – 2:00 – 3:15 pm; Philipp Scherer, PhD – Director, Touchstone Diabetes Center, UT Southwestern Medical Center
“Adipose Tissue Organ Crosstalk in Health and Disease“ - Closing/Awards – 3:15 – 3:30 pm
- Reception – 3:30 – 4:00 pm
Posters
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1 Loss of Glp-1r signaling in the β-cell Impairs Adaptive Proliferation and Insulin Secretion Angela Olvera, Samuel Saghafi, Arnaldo de Souza, Jaiyin Tang, Amanjot Yadev, Riley Meyer, Dawn B Davis |
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2 Islet architecture in adult mice is actively maintained by Robo2 expression in β cells Bayley J. Waters, Barak Blum |
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3 A Shift in the Human Plasma Lipidome with Metformin Monotherapy Independent of Glycemic Control in a Type 2 Diabetes Clinical Cohort Benjamin Wancewicz, Yanlong Zhu, Rachel J. Fenske, Alicia M. Weeks, Kent Wenger, Samantha Pabich, Michael Daniels, Margaret Punt, Randall Nall, Darby Peter, Allan Brasier, Elizabeth D. Cox, Dawn B. Davis, Ying Ge, and Michelle Kimple |
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4 “Humanizing” mouse environments YIldiko Kasza, Colleen Cuncannan, Julian Michaud, Dave Nelson, Chi-Liang E. Yen, Raghav Jain, Judi Simcox, Ormond MacDougald, Brian Parks and Caroline M. Alexander |
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5 Variation in mouse islet Ca2+ responses reveals novel regulators of human islet function. Christopher H. Emfinger, Lauren E. Clark, Kathryn L. Schueler, Shane P. Simonett, Donnie S. Stapleton, Kelly A. Mitok, Matthew J. Merrins, Mark P. Keller, Alan D. Attie |
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6 Targeting brown adipocyte heme biosynthesis to treat obesity and type 2 diabetes Dylan J. Duerre, Julia K. Hansen, Mindy Yadev, Andrea Galmozzi |
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7 Leucine reduces glucagon secretion by directly modulating alpha cell cAMP Emily R. Knuth, Hannah R. Foster, and Matthew J. Merrins |
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8 Mass Spectrometry Analysis of O-Glycosylation in Human Pancreatic Tissue Feixuan Wu, Dylan Nicholas Tabang, Daniel M. Tremmel, Megan Ford, Sara Dutton Sackett, Jon S. Odorico, Lingjun Li |
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9 Prostaglandin Reductase 2 Inhibitor as a Potential Treatment for Type 2 Diabetes Hoang Bui, Andrea Galmozzi |
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10 Deletion of XBP1 in beta cells of NOD mice protects against type 1 diabetes Hugo Lee, Yash Sonthalia, Julia Dorris, Brett Pontelandolfo, Feyza Engin |
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11 Signaling Properties and Islet Insulin Secretion Effects of Human EP3 Receptor Splice Variants Jamie L. Colon, Cecilia E. Kaiser, Chinmai Patibandla, Darby C. Peter, Michael D. Schaid, Peter J. Chlebeck, Sara D. Sackett, Jon S. Odorico, and Michelle E. Kimple |
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12 Placental fatty acid transport and metabolism in a rat model of gestational diabetes mellitus Jay S Mishra, Sri Dangudubiyyam, Ruolin Song, and Sathish Kumar |
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13 Thioredoxin reductase 1 is required for maintenance of pancreatic beta-cell function and identity Jennifer S. Stancill, Polly A. Hansen, Angela J. Mathison, Edward E. Schmidt, and John A. Corbett |
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14 Loss of Transcription Factor 19 (Tcf19) Impacts Metabolic Response to Stress Joseph T Blumer, Jee Young Han, Keelin Ricciardi, Sam Saghafi, Anya Beric, Grace H Yang, Sukanya Lodh, Danielle A Fontaine, Dawn B Davis |
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15 BET bromodomain inhibition attenuates p65-driven transcription of a subset of NF-κB gene targets in pancreatic β-cells Joshua A. Nord, Sarah L. Wynia-Smith, Rachel A. Jones Lipinski, Alyssa L. Gehant, Aaron Naatz, John A. Corbett, Brian C. Smith |
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16. The genetics of diet-responsiveness Kelly A. Mitok, Kathryn L. Schueler, Donald S. Stapleton, Qiushi Sun, Rebecca L. Cardone, Gary A. Churchill, Richard G. Kibbey, Mark P. Keller, and Alan D. Attie |
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17 Hnf4a regulates hepatic fatty acid elongation and peroxisomal biogenesis during the thermogenic response Helaina Von Bank, Gisela Geoghegan, Raghav Jain, Paula Gonzalez, Mae Hurtado-Thiele, Charlie Kirsh, Ian Huck, Udayan Apte, and Judith Simcox |
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18. Functionalizing a T2D-associated locus within an intron of GLIS3 Lauren E. Clark, Kathryn L. Schueler, Leesa L. Sampson, Shane P. Simonett, Donnie S. Stapleton, Jean-Philippe Cartailler, Kelly A. Mitok, Chris H. Emfinger, Mark A. Magnuson, Alan D. Attie, Mark P. Keller |
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19 β-cell specific deletion of Ormdl3 does not affect whole-body glucose metabolism Liam Hurley, Hugo Lee, Feyza Engin |
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20 Restriction of the branched-chain amino acids and methionine have different effects on metabolic health Mariah Calubag, Reji Babygirija, Ismail Ademi, Chung-Yang Yeh, Michelle Sonsalla, Ryan Matoska, John Michael, Alyssa Bhoopat, Michaela Murphy, Cara Green, Dudley W. Lamming |
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21. Feasibility and Acceptability of a Culturally Tailored Diabetes Self-Management Program Incorporating Peer Support Intervention for African Americans Meng-Jung Wen, Martha Maurer, Luke Schwerer, Nassim Sarkarati, Ejura Yetunde Salihu, Jenna Nordin, Phanary Xiong, Ugboaku Maryann Egbujor, Sharon D. Williams, Olayinka Shiyanbola |
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22 Acarbose Improves Metabolic Health and Cognitive Function in a Diet-Induced Obese Mouse Model of Alzheimer’s Disease Michelle Sonsalla, Reji Babygirija, Chung-Yang Yeh, Michaela Trautman, Cara Green, Victoria Flores, Mariah Calubag, Dudley W. Lamming |
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23 Gluocse mediated upregulation of Cck expression independent of cAMP signaling Rashaun A. Williams, Matthew T. Flowers, Dawn Belt Davis |
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24 Hepatic Deletion Of FOXO1 Signaling Rescues the Metabolic Deficits Caused By mTORC2 Inhibition Reji Babygirija, Michelle Sonsalla, Mariah Calubag, Michaela Murphy, Chung-Yang Yeh, Cara Green, Heidi Pak, Dudley Lamming |
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25 Fuel-dependent regulation of ER Ca2+ in pancreatic β-cells Shih Ming Huang, Hannah R. Foster, Matthew J. Merrins |
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26 Incretins recruit pyruvate kinase to amplify insulin secretion Sophie L. Lewandowski, Hannah R. Foster, Kimberly El, Megan E. Capozzi, Jonathan E. Campbell, and Matthew J. Merrins |
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27 Characterizing the role of the RNA-binding protein Cpeb1 in β cells Sutichot Nimkulrat, Hariharan Jayaraaman, Bayley Waters, Zoe Birman, Lauren Simone, Barak Blum |
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28 Identification of Asah2 as a novel driver of HDL-cholesterol and lipoprotein subclasses Tara R. Price, Rebekah Nicholson, Ronald M. Krauss, William L. Holland, Mark P. Keller, Alan D. Attie |
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29 A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in human pancreatic α and β-cells Thuong Ho, Evgeniy Potapenko, Patrick E. MacDonald, Matthew J. Merrins |
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30 Low isoleucine dietary intervention in aged mice Chung-Yang Yeh, Lucas C.S. Chini, Meredith S. Gallagher, Isaac T. Freichels, Mariah F. Calubag, Reji Babygirija, Shelly Sonsalla, Michaela E. Trautman, Cara L. Green, Heidi H. Pak, Dudley W. Lamming |