Jonathan Engle

For this P30 application for the Wisconsin Diabetes Research Center (WDRC), the University of Wisconsin Cyclotron Group will produce Mn-51 chloride as a positron emission tomography (PET) tracer to be used as a non-invasive quantitative biomarker of pancreatic β-cell mass and diabetes pathology in small animal models. We will also assist in the production of other radiochemicals, as needed, by WDRC investigators in their diabetes research. With over a decade in radionuclide production and application in various fields, and as the PI or co-Investigator on numerous initiatives funded by Los Alamos National Laboratory, the National Nuclear Security Administration, and the Department of Energy’s National Isotope Program, I have successfully applied my knowledge to the formation, purification, chemical modification and application of many different radionuclides at scales ranging from global commercial markets to unique, single effort support of novel single-investigator research. I have been directly responsible for the production of numerous radionuclides for basic science, preclinical and clinical research (e.g., 18F, 13N, 15O, 11C, 89Zr, 34mCl, 68/66Ga, 52Mn, 86Y, 55/57Co, 82Sr, 68Ge, 225Ac, 230U, 86Y, and 64Cu, among many others). I have a deep understanding of the targetry and radiochemistry necessary to these processes and of the relevant radiochemical and radiobiological considerations germane to clinical purposes.