My lab is interested in whole body and musculoskeletal metabolism of aging with interests in insulin resistance, skeletal muscle health, and osteoarthritis. The overall theme of my laboratory is to use a translational research approach to understand the mechanisms involved in the pathogenesis and treatment of aging and age-related disease. My major goal is to take findings from tissue culture, rodents, and non-human primates and test in human clinical trials. I have led multiple NIH and industry-funded human clinical trials to test whether strategies that extend healthspan and lifespan in mice can be safely translated to humans. For the past 8 years, I have conducted clinical trials testing the potential of metformin to promote healthy aging in insulin resistant and insulin sensitive individuals. We utilize various measures of glucose control including hyperinsulinemic-euglycemic clamps, oral glucose tolerance test, mixed-meal tolerance tests and continuous glucose monitoring in participants ranging from lean to obese and young to old.