Position title: Assistant Professor
My lab is interested in whole body and musculoskeletal metabolism of aging with interests in insulin resistance, skeletal muscle health, and osteoarthritis. The overall theme of my laboratory is to use a translational research approach to understand the mechanisms involved in the pathogenesis and treatment of aging and age-related disease. My major goal is to take findings from tissue culture, rodents, and non-human primates and test in human clinical trials. I have led multiple NIH and industry-funded human clinical trials to test whether strategies that extend healthspan and lifespan in mice can be safely translated to humans. For the past 8 years, I have conducted clinical trials testing the potential of metformin to promote healthy aging in insulin resistant and insulin sensitive individuals. We utilize various measures of glucose control including hyperinsulinemic-euglycemic clamps, oral glucose tolerance test, mixed-meal tolerance tests and continuous glucose monitoring in participants ranging from lean to obese and young to old.