Position title: Assistant Professor of Nutritional Sciences
In our lab, we leverage mouse and human genetics data to discover genes and pathways that contribute to metabolic diseases. Most recently, my laboratory has developed a systematic approach to integrate big data from both mice and humans to discover unknown genes involved in lipid metabolism. From this work, we identified and validated Sestrin1 as a gene that mediates feedback inhibition on cholesterol biosynthesis. Related to diabetes, we have constructed SNP-SNP interaction maps in the mouse and are currently using these maps to investigate modifiers of key metabolic signaling pathways (FOXO1 and PPAR gamma) that contribute to diabetes and obesity.